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Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at FDA-1088. Cialis can also cause some rare but serious side effects. An erection lasting longer than 4 hours (priapism) is one example. There have also been reports of vision and hearing loss. If you experience any of these side effects, it s important to seek medical care right away. 8. Cialis can treat more than erectile dysfunction side effects of cialis 20mg The side effects of generic Cialis are similar to the side effects of Cialis. Common side effects can include: indigestion; muscle pain; headaches; heartburn; Rare, but very serious, side effects Does tadalafil have side effects? The most common side effects of tadalafil include: headache; indigestion or heartburn; back pain; muscle aches; flushed skin; stuffy or runny nose; These side effects usually go away after a few hours. Very occasionally, tadalafil can cause a painful erection or an erection that won t go away (priapism).